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Abstract

An In vivo Assessment of Diabetes Ameliorating Potentiality of Ethanolic Extract of Cynodondactylon on AlloxanInduced Diabetic Rat Model

Diabetes is a metabolic disorder. Some plant-derivative products are used to oppose this life-threatening complication. The plant is an assorted source of diverse healing compounds that can be used to ameliorate diabetes. Cynodondactylon is a grass species traditionally used for several medicative objectives from ancient times. It has also been used to ease diabetes. We intended to determine the hypoglycemic outcome of C. dactylon extract and ascertain its safety profile. Diabetes was induced in rats via injecting alloxan (150 mg/kg) through the intraperitoneal route. After assessing the blood glucose level, it has been observed that the Ethanolic extract of C. dactylon (750 mg/kg) could significantly decrease the blood sugar level compared to the positive control group (p<0.05). Besides, the extract’s hypoglycemic efficiency was comparable with metformin with null statistical significance (p>0.05). As a part of the safety profile analysis, we measured SGOT, SGPT, Creatinine, and the lipid profile levels of rats belonging to different groups. It was seen that both metformin and extract of C. dactylon improved the pathological conditions induced by diabetes. Furthermore, in healthy individual rats, both metformin and extract of C. dactylon did not significantly alter the sound pathological state. Hence, it might be assumed that the extract of C. dactylon could be practiced as an excellent alternative therapy to ameliorate diabetes.


Author(s):

Md. Rafat Tahsin, Md. Tajbiul Alam Bhuiyan, Arifa Sultana, Lia Rose Merry D. Cruze, Tahmina Sharif Nila, Mokaddas Flora Ananta, Tanzia Islam Tithi, FurhatunNoor, Fahima Jannat Koly, Samiha Sayeed and Md. Shah Amran



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