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Abstract

Application of Peptides and Proteomics in the Diagnosis and Management of Pancreatic Cancer

Pancreatic Cancer is one of the leading causes of oncological-related death around the globe. It is difficult to resect surgically and resistant to many forms of traditional chemotherapy due to the presence of cancer stem cells. The prognosis is worsened due to the insidious onset of symptoms, leading to delayed detection and diagnosis, and hindering the effectiveness of treatment due to the advanced stage of metastatic disease. This review seeks to contribute to the development of novel diagnostic techniques and management of Pancreatic Cancer by elucidating recent advances in peptide research and proteomic biotechnology. Peptides and proteomics can help detect tumor presence earlier with more accuracy, enhance the delivery of pharmacological agents and perform various immunomodulatory and antineoplastic roles. When combined with traditional cancer therapy, peptides and proteomics have the potential to give future clinicians more useful tools to help their patients.


Author(s):

Yichi Zhang, Katie Cironi, Emily Zlotnick, Jenna Ransom, Natalie Suder, Magnus Chun, Elizabeth Holland, Qiping Zheng, Jun He and Lichun Sun



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