Introduction: Coronary artery bypass grafting is one of the primary treatment for coronary artery disease and is referred as one of the most common surgical procedure. This surgery has an impact on quality of life. Factors that affected it in patients underwent this kind of surgery are psychosocial, demographic factors and patient related characteristics. Purpose: The aim of the present study was to investigate the quality of life of patients underwent coronary artery bypass graft after six months of it and to determine the factors influencing the quality of life of these patients. Material-Method: The sample was convenience and consisted of 84 patients underwent coronary artery bypass grafting surgery before six months in one hospital of a major city in Northern Greece. Data were collected with a questionnaire that included the SF-36 and socio-demographic characteristics. Data analysis was performed with the Statistical Package SPSS vers.15. Results: The sample was predominately male (n= 61, 72, 6%) and a high percentage of them is above 50 years (85, 7%). The domains of quality of life that have higher means are: role emotional (68, 25 ± 40, 71), role physical (55 ± 33, 13), vitality (53, 99 ± 20, 97) and social functioning (45, 09 ± 22, 71). Some of the factors that are significantly correlated with various domains of quality of life were patients’ sex, nationality, occupational status smoking, family status, educational status and comorbities. Conclusions: The main domains of quality of life that affected are physical functioning, bodily pain, social functioning and mental health, so health care professionals have to plan interventions to improve it.