The coronavirus disease 19 (COVID-19) is a highly transmissible and pathogenic viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in Wuhan, China and spread quickly worldwide in December 2019. This review article aims to improve the readers’ awareness about the COVID-19 vaccine and benefits of vaccinations. This article reviewed existing evidence on the immune response against SARS coronaviruses in order to understand the possible outcome of a vaccine for COVID-19. Further, explored the study on age-dependent immune responses against SARS-CoV-2 after vaccination. Finally, present and future progress requirement towards the development of safe and effective COVID-19 vaccines are discussed.