Evaluation of Clinical and biochemical characteristics and Genetic Association Between the Polymorphic loci in Diabetic mellitus 2 patients in Urmia

Abstract

Background

 Predisposing factors of type 2 diabetes are multi-factorial and factors such as genetics and the environment are involved in its outbreak. The aim of the current study was to analyze the genetic relationships between ATF6rs2070150: G> C and FTOrs8050136: A> C gene variants with clinical and biochemical parameters belong to the patients of type 2 diabetes in Imam Khomeini Hospital of Urmia.

Methods

 The present study is a case-control study. 100 patient's blood samples along with 100 healthy control samples for ATF6rs2070150: G> C and FTOrs8050136: A> C variants were tested using Tetra-arms PCR method.

Results

Although the frequency of genotypes were comparable between patients and healthy control subjects, the logistic regression analysis showed no significant relationship between FTO rs8050136 A allele and ATF6rs2070150 C allele with an increased risk of type 2 diabetes. Also,the A allele from FTO and C allele from ATF6 were significantly associated with increased levels of HbA1c, insulin, HOMA-IR, diastolic blood pressure and obesity markers (BMI, waist and hip circumference). In the present study, there was a significant relationship between FTO rs8050136 A> C and ATF6rs2070150: G>C with main markers of type 2 diabetes such as insulin resistance, obesity and inflammation.

Conclusions

These findings can provide new opportunities for the prevention, diagnosis and customization of type 2 diabetes in the future. In particular, the prevention of obesity in some dangerous genetic subgroups may be a valuable contribution to the prevention of type 2 diabetes.

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