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Abstract

Fluorescence Immunoassay System Plays an Important Role in Timely Diagnosis of COVID-19 Infection

Objective: Mainly compare the differences between PCR; antibody, antigen tests with Fluorescence Immunoassay Analyzer for COVID-19.

Methods: Compare the sensitivity, specificity and the accuracy of different manufacturers’ COVID-19 antibody and antigen tests with Fluorescence Immunoassay Tests. Different onset time samples were tested with RT-PCR and fluorescence immunoassay COVID-19 antibody and antigen tests. Total 365 specimens were used in clinical study at different locations (Spain, Slovenia and United States). The sample used for fast detection of COVID-19 antigen was nasopharyngeal swab. Three kinds of sample used in the detection of novel coronavirus antibodies were venipuncture/ finger stick whole blood and serum. The fluorescence immunoassay analyzer detects the fluorescence signal value of a specific area and calculates the result of the SARS-CoV- 2 Antigen and Antibody in the sample according to the algorithm on the ID card.

Results: The emergence of various COVID-19 fluorescence immunoassay test enables us to complete the preliminary screening. Antigen (Ag) tests that directly detect the SARS-CoV-2 virus antigen, and antibody (Ab) tests that detect one or more types of antibodies produced by the host immune response against the virus. The detection rate of COVID-19 antibody was increased with the increase of the onset time of patients, while the detection rate of antigen was decreased gradually, which was corresponding to the nature of antigen and antibody in the human body.

Conclusion: Different detection methods have their own advantages in different application fields. We through products (FIATEST, SOFIA, BINAXNOW) in antigen detection and products (FIATEST, SD BIOSENSOR, BODITECH) in antibody detection to predict the advantages of convenient and sample collection, high throughput, low workload, high reproducibility and low cost in practical applications.


Author(s):

Zhang Lei, Yang Feng and Zhu Junzhe



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Abstracted/Indexed in
  • Google Scholar
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
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  • Directory of Research Journal Indexing (DRJI)
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  • WorldCat
  • University Grants Commission
  • Geneva Foundation for Medical Education and Research
  • Secret Search Engine Labs
  • Euro Pub

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