Single Nucleotide Polymorphism (Rs4804803) in the DC-SIGN Promoter Region Cd209, and Implications Regarding the Susceptibility to Chronic Periodontitis in Individuals with Type 2 Diabetes Mellitus

Chronic periodontitis (CP) is a disease caused by an impaired immune response to oral bacteria and is often found in individuals with type 2 diabetes mellitus (DM2). Dendritic cells are involved in CP and genetic polymorphisms in the DC-SIGN receptor may modulate susceptibility to the disease. The aim of the study was to investigate the distribution of a single nucleotide polymorphism in the DC-SIGN in individuals with DM2 and CP, non-DM2 individuals with CP and healthy controls and its association with CP in a sample of population. 280 individuals (116 with DM2+CP, 95 with CP and 69 healthy controls) were genotyped using real-time PCR with allelespecific probes. Significant differences (p<0.05) were found among the groups with regard to socioepidemiological variables, as well as clinicalepidemiological variables. With regard to allelic and genotypic distribution, the GG genotype was significantly more frequent among the healthy individuals compared to those with DM2+CP, suggesting less susceptibility to DM2+CP (p=0.030). The AG genotype was also associated with a lower bleeding index compared to the AA genotype in healthy individuals (p=0.016). This is the first record of an association between a variant in DC-SIGN and susceptibility to DM2 and CP.

Author(s):

Roberto Carlos Mourao Pinho, Rayanne Soraia Aguiar de Melo Dias, Jessyca Kalynne Farias Rodrigues, Erinaldo Ubirajara Damasceno dos Santos, Gabriela Mendonça Luna, Francisco Bandeira, Ronaldo Celerino da Silva, Sergio Crovella and Renata Cimoes

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