Background: Nosocomial infections are a significant problem in global healthcare setting. Nurses have an important role in transmitting and preventing nosocomial infections. Objective: This review investigated nurses’ knowledge, practices attitudes about nosocomial infections. It aimed to unfold differences between nurses in terms of working in general settings and intensive care unit (ICU), working as a beginner and as experienced, and the extent of impact of the organizational support offered to nurses on their knowledge, attitudes, and practices. Methods: To achieve the objective of the study, a review of the published literature was undertaken, utilizing four electronic databases. Nine studies out of eighteen were included based on the author's criteria of selection, which were published 2012-2017 Findings: Variability was found in nurses’ knowledge, attitudes, and practices in relation to nosocomial infections. This variability persists in nurses working in different settings. The findings revealed a positive significant correlation between nurses’ practice experience, and their knowledge, attitudes, and practices and between nurses’ knowledge, attitudes and practices and organizational support. Conclusion: The review has contributed to identifying how nurses’ knowledge, attitudes and practice can be improved to enable them to contribute more effectively to nosocomial infection prevention.