The Pathogenesis and Therapeutics of Nasopharyngeal Carcinoma

Nasopharyngeal carcinoma (NPC) is a squamous cell carcinoma and arises from nasopharynx epithelium, with a geographical and racial distribution. NPC is rare all over the world, but particularly prevalent in Southern China. NPC has been demonstrated to be strongly associated with environmental factors, genetic susceptibility and viral infection, especially Epstein–Barr virus (EBV) infection. NPC is also radio-sensitive and chemo-sensitive. Thus, radiotherapy and chemotherapy are traditional strategies for NPC treatments. However, recurrence frequently occurred in patients after NPC therapeutics. As with the development of new scientific technologies, we get chances to open our mind and dig deep down inside NPC and EBV. A well-understanding of such NPC genetics, gene aberration, non-coding RNA and EBV-associated exosomes, is and will be very helpful for us to promote NPC treatments or develop novel anti-NPC/anti-EBV drugs.

Author(s):

Ji-Qun He, Lichun Sun, Jun He, Chenhong Zhu, Ping Li, Jun Lei, Quanyong He, Vienna Mackey, Zhen Lin, Pengfei Cheng and David H Coy

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